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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (10): 1370-1377. 上一篇    下一篇

综述与进展

抗霉素合成概览

杨永青，伍贻康*   

  1. (中国科学院上海有机化学研究所生命有机化学国家重点实验室 上海 200032)
  • 收稿日期:2006-05-29 修回日期:2006-07-19 发布日期:2006-09-19
  • 通讯作者: 伍贻康

A Survey of Synthesis of Antimycins

YANG Yong-Qing,WU Yi-Kang*   

  1. (State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemis-try,
    Chinese Academy of Sciences, Shanghai 200032)
  • Received:2006-05-29 Revised:2006-07-19 Published:2006-09-19
  • Contact: WU Yi-Kang

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被引次数

9 | 2

抗霉素(antimycin)是一大类具有九元环双内酯的天然抗生素, 最早发现于20世纪40年代末. 在随后的50多年中不断地有新的成员被发现, 到目前为止已多达26个. 这类化合物的结构主要是通过抗霉素A3b来确定的, 所以合成工作也是围绕该成员展开的. 对文献中已有报道的合成工作加以综述, 对各方法的主要优缺点也进行了简要的分析.

关键词: 对映体选择性合成, 关环反应, 抗生素, 内酯

Antimycins are a large family of natural antibiotics featuring a nine-membered dilactone ring. The name of antimycin could be traced back to the late 1940’s. Since then, new antimycins are continuingly added to the list of this interesting class of compounds, which now already includes as many as 26 closely related individuals. Probably due to structural determination was mainly done on antimycin A3, synthetic endeavors up to now are carried out exclusively on the A3 (mostly A3b). The enantioselective syntheses spread over the last decades are reviewed, with the merits and shortcomings briefly discussed.

Key words: enantioselective synthesis, ring-closure, lactone, antibiotics