SIOC English
有机化学
高级检索

有机化学 ›› 2006, Vol. 26 ›› Issue (10): 1424-1428. 上一篇    下一篇

研究简报

溴代二羟基二苯醚类化合物的合成与抑菌活性研究

金洪a，陈鸶a，侯若彤b，王玉良*,a
陈淑华a，杨志荣b   

  1. (a四川大学化学学院 成都 610064)
    (b四川大学生命科学学院 成都 610064)
  • 收稿日期:2005-12-15 修回日期:2006-02-27 发布日期:2006-09-19
  • 通讯作者: 王玉良

Study on the Synthesis and Antimicrobial Activities of Brominated Dihydroxy Diphenyl Ethers

JIN Honga,CHEN Sia,HOU Ruo-Tongb,WANG Yu-Liang*,a
CHEN Shu-Huaa,YANG Zhi-Rongb   

  1. (a College of Chemistry, Sichuan University, Chengdu 610064)
    (b College of Life Science, Sichuan University, Chengdu 610064)
  • Received:2005-12-15 Revised:2006-02-27 Published:2006-09-19
  • Contact: WANG Yu-Liang

PDF

1070

被引次数

20

设计并合成了7个新的溴代2,2'-, 2,4-'和4,4'-二羟基二苯醚; 所有这些化合物的结构均经1H NMR, MS, IR和元素分析所证实; 新化合物的结构避免了现有二苯醚杀菌剂在生产和使用过程中有可能生成高毒性二噁类化合物的缺点; 并选择8种有害菌对合成的新的溴代二羟基二苯醚进行了抑菌活性测试, 结果表明它们对所测试菌种具有很好的抑制活性, 与目前国内外广泛使用的广谱抗菌剂三氯新的抑菌活性相当.

关键词: 溴代二羟基二苯醚, 合成, 抑菌活性

Seven brominated dihydroxy diphenyl ethers have been designed and synthesized. Structures of new compounds have been confirmed by 1H NMR, MS, IR spectra and elemental analysis. These new compounds have the advantage in avoiding producing the severe toxicity of dioxins in the course of manufacturing and using. The bioactivity testing showed that these compounds possessed good antimicrobial activities toward the tested bacterium.

Key words: synthesis, antimicrobial activity, brominated dihydroxy diphenyl ether