有机化学 ›› 2017, Vol. 37 ›› Issue (4): 908-913.DOI: 10.6023/cjoc201610027 上一篇    下一篇

研究论文

新型碳硫双手性含吡啶结构的邻苯二甲酰胺类化合物的设计、合成与生物活性研究

孟祥德, 周沙, 解永涛, 赵毓, 熊丽霞, 周莎, 李正名   

  1. 南开大学元素有机化学研究所 元素有机化学国家重点实验室 天津 30071
  • 收稿日期:2016-10-17 修回日期:2016-12-11 发布日期:2017-01-10
  • 通讯作者: 周莎, 李正名 E-mail:mengsha171657@163.com;nkzml@vip.163.com
  • 基金资助:

    国家自然科学青年基金(No.21602118)、天津化学化工协同创新中心资助项目.

Design, Synthesis and Biological Activities of Novel Dual-Chiral Carbon and Sulfur Pyridine Phthalic Acid Diamide Derivatives

Meng Xiangde, Zhou Sha, Xie Yongtao, Zhao Yu, Xiong Lixia, Zhou Sha, Li Zhengming   

  1. State Key Laboratory of Elemento-organic Chemistry, Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071
  • Received:2016-10-17 Revised:2016-12-11 Published:2017-01-10
  • Contact: 10.6023/cjoc201610027 E-mail:mengsha171657@163.com;nkzml@vip.163.com
  • Supported by:

    Project Supported by the National Natural Science Foundation of China (No. 21602118), and the Collaborative Innovation Center of Chemical Science and Engineering (Tianjin).

为了开发高效、低毒、环境友好型绿色生态杀虫剂,通过研究含有两个手性中心的硫亚胺和亚磺酰亚胺类结构的构效关系,引入吡啶环,设计合成了新型碳硫双手性含吡啶结构的邻苯二甲酰胺类化合物,其结构通过NMR,HRMS分析确认. 初步的生测结果表明,大部分化合物表现中等的杀虫活性. 本结果为含有双手性硫亚胺和亚磺酰亚胺结构的双酰胺类化合物的研究奠定了一定的理论基础.

关键词: 吡啶, 邻苯二甲酰胺, 合成, 杀虫活性, 双手性

In order to find efficient, low toxicity, eco-friendly insecticides, novel chiral carbon and sulfur phthalic acid diamide derivatives containing pyridine substitute were designed and synthesized for further studying the structure-activity relationship of dual-chiral sulfilimines and sulfoximines. Their structures were confirmed by NMR and HRMS. The preliminary results of biological evaluation showed that the most compounds exhibited moderate larvicidal activity. These results provide a theoretical basis for the study of the dicarboxamide structures containing sulfiliminyl and sulfoximinyl moieties.

Key words: pyridine, phthalic acid diamides, synthesis, insecticidal activity, dual-chiral