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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (03): 462-465. 上一篇    下一篇

研究简报

ZnCl2温和有效地催化活泼亚甲基化合物与苄醇或烯丙醇的 直接烷基化反应

吴 俊a ; 叶家海*,b; 胡劲松a ; 王智勇b; 商永嘉*,a   

  1. (a安徽师范大学化学与材料科学学院 安徽省分子固体重点实验室 芜湖 241000)
    (b南京理工大学化工学院 南京 210094)
  • 收稿日期:2008-03-03 修回日期:2008-09-02 发布日期:2009-03-20
  • 通讯作者: 叶家海,商永嘉

A Mild and Highly Efficient ZnCl2-Catalyzed Direct Alkylation of Active Methylene Compounds with Benzylic and Allylic Alcohols

Wu, Juna ; Ye, Jiahai*,b; Hu, Jinsonga ; Wang, Zhiyongb; Shang, Yongjia*,a   

  1. (a Anhui Key Laboratory of Functional Molecular Solids, College of Science and Material Science,
    Anhui Normal University, Wuhu 241000)
    (b School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094)
  • Received:2008-03-03 Revised:2008-09-02 Published:2009-03-20
  • Contact: Ye, Jiahai; Shang, Yongjia

PDF

1262

被引次数

4

报道了ZnCl2催化的活泼亚甲基化合物和苄醇或烯丙醇的直接烷基化反应. 在无水ZnCl2 (5～10 mol%)的催化下, 以二氯甲烷为溶剂, 活泼亚甲基化合物和苄醇或烯丙醇进行直接烷基化反应以较高的收率得到活泼亚甲基化合物的烷基化产物, 反应后处理简单, 说明ZnCl2是一种温和有效的活泼亚甲基化合物和苄醇或烯丙醇进行直接烷基化的催化剂. 并对反应的机理进行了初步研究.

关键词: 烷基化, 活泼亚甲基化合物, ZnCl2催化

A mild and highly efficient ZnCl2-catalyzed direct alkylation of active methylene compounds with benzylic and allylic alcohols has been reported. The alkylation was carried out in the presence of sub-stoichiometric amounts of anhydrous ZnCl2 (5～10 mol%) under reflux in dichloromethane with high yields. It is an easy handling and atomic-economic reaction and water is the only side product. The possible mechanism for this direct alkylation has preliminary studied as well.

Key words: alkylation, active methylene compound, ZnCl2-catalyzed