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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (01): 42-52. 上一篇    下一篇

综述与进展

Saframycins 及Ecteinascidins化合物的合成研究进展

王晔，唐叶峰 刘站柱*，陈世智，梁晓天   

  1. (中国医学科学院中国协和医科大学药物研究所 北京 100050)
  • 收稿日期:2004-03-01 修回日期:2004-06-01 发布日期:2004-12-30
  • 通讯作者: 刘站柱

Synthetic Progress in Saframycins and Ecteinascidins

WANG Ye,TANG Ye-Feng,LIU Zhan-Zhu*,CHEN Shi-Zhi,LIANG Xiao-Tian   

  1. (Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences,
    Beijing 100050)
  • Received:2004-03-01 Revised:2004-06-01 Published:2004-12-30
  • Contact: LIU Zhan-Zhu

PDF

2169

被引次数

10

综述了两类双四氢异喹啉生物碱Saframycins和Ecteinascidins的合成研究进展. 分析了各合成路线的关键步骤, 部分讨论了各方法的优缺点, 并对其生物合成和作用机理作了简单介绍.

关键词: 双四氢异喹啉生物碱, saframycin, ecteinascidin, 合成, phthalascidin

The tetrahydroisoquinoline antitumor antibiotics have been studied thoroughly over the past 30 years. This paper reviews the synthetic progress in two kinds of bis-tetrahydroisoquinoline alkaloids, saframycins and ecteinascidins. The key reaction of each synthetic route has been analyzed. Both applications and limitations of these approaches were discussed. Some views on the biosynthesis and mechanism of action were summarized too.

Key words: saframycin, bis-tetrahydroisoquinoline alkaloid, ecteinascidin, synthesis, phthalascidin