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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (08): 881-892. 上一篇    下一篇

综述与进展

手性辅基法不对称合成特殊结构α-氨基酸——甘氨酸等当体途径

李振江*，万红贵，韦萍，石玉瑚，欧阳平凯   

  1. (1南京工业大学制药与生命科学学院 南京210009)
    (2新疆大学化学与化工学院 乌鲁木齐830046)
  • 收稿日期:2004-06-25 修回日期:2004-12-03 发布日期:2005-07-30
  • 通讯作者: 李振江

Asymmetric Synthesis of Tailor-made α-Amino Acids by ChiralAuxiliaries: Glycine Equivalent Approach

LI Zhen-Jiang*,WAN Hong-Gui,WEI Ping,SHI Yu-Hu
OUYANG Ping-Kai   

  1. (1 College of Life Science and Pharmaceutical Engineering, Nanjing University of Tech-nology, Nanjing 210009)
    (2 College of Chemistry and Chemical Engineering, Xinji-ang University, Urumqi 830008)
  • Received:2004-06-25 Revised:2004-12-03 Published:2005-07-30
  • Contact: LI Zhen-Jiang

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特殊结构的α-氨基酸对于生命过程研究和生物医药开发有重要意义. 不对称合成α-氨基酸的方法学中, 手性辅基方法是较多研究和应用的领域. 介绍了该方法近二十年来的发展, 对近十年的甘氨酸等当体合成策略做了详尽述评.

关键词: α-氨基酸, 不对称合成, 甘氨酸等当体, 手性辅基

Tailor-made α-amino acids have played an important role in current life science research and biomedical development. Among the methodologies of α-amino acid asymmetric synthesis, chiral auxiliary strategy received most intensive and extensive investigations. Recent development in this strategy was outlined. Detailed critical review on the glycine equivalent approach in the last ten years was given.

Key words: asymmetric synthesis, chiral auxiliary, glycine equivalent, α-amino acid