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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (11): 1584-1586. 上一篇    下一篇

研究简报

N-(1,2,4-三唑并[1,5-a]嘧啶-2-基)-N′-芳酰基硫脲的合成与生物活性

王胜a，王胜a，冯桂荣b，刘国华c，叶文法a，汪焱钢*,a   

  1. (a华中师范大学化学学院 武汉 430079)
    (b唐山师范学院化学系 唐山 063000)
    (c上海师范大学生命与环境科学学院 上海 200243)
  • 收稿日期:2005-11-26 修回日期:1900-01-01 发布日期:2006-10-27
  • 通讯作者: 汪焱钢

Synthesis and Biological Activity of N-(1,2,4-Triazolo- [1,5-a]pyrimidin-2-yl)-N′-aroyl Thioureas

WANG Shenga,FENG Gui-Rongb,LIU Guo-Huac,YE Wen-Faa,WANG Yan-Gang*,a   

  1. (a College of Chemistry, Central China Normal University, Wuhan 430079)
    (b Department of Chimistry, Tangshan Narmal University, Tangshan 063000)
    (c College of Life and Environment Science, Shanghai Normal University, Shanghai 200243)
  • Received:2005-11-26 Revised:1900-01-01 Published:2006-10-27
  • Contact: WANG Yan-Gang

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通过2-氨基-5,7-二甲基-1,2,4-三唑并[1,5-a]嘧啶同芳酰基异硫氰酸酯反应, 合成了12种新的含杂环基的芳酰基硫脲, 用红外光谱、核磁共振氢谱和元素分析确证了其结构, 初步的生物活性测定试验表明部分目标化合物具有良好的生物活性, 尤其是对于双子叶植物表现出较高的除草活性.

关键词: 芳酰基硫脲, 三唑并嘧啶, 除草活性, 合成

Twelve novel aroyl thioureas containing heterocyclic radical have been synthesized by the reaction of 2-amino-5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine with aroyl isothiocyanates. Their structures were confirmed by 1H NMR, IR spectra and elemental analysis. The preliminary biological activity tests showed that some title compounds have good biological activity and better selective herbicidal activity to dicotyledon.

Key words: triazolo[1,5-a]pyrimidine, synthesis, herbicidal activity, aroyl thiourea