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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (04): 432-437. 上一篇    下一篇

研究论文

[1-芳基甲羰基-2-(1,2,4-三唑-1-基)]乙基-N,N-二烷基二硫代氨基甲酸酯衍生物的合成、结构表征及生物活性研究

建方方*，许良忠，文丽荣，朱崇毅   

  1. (青岛科技大学新材料和功能配合物实验室 青岛 266042)
  • 收稿日期:2004-04-05 修回日期:2004-11-10 发布日期:2005-03-30
  • 通讯作者: 建方方

Synthesis, Structure Characterization and Biological Activities of Aromatic Triazole Compounds Containing N,N-Dialkyldithiocarbamate

JIAN Fang-Fang*,XU Liang-Zhong,WEN Li-Rong,ZHU Chong-Yi   

  1. (New Materials & Function Coordination Chemistry Laboratory, Qingdao University of
    Science and Technology, Qingdao 266042)
  • Received:2004-04-05 Revised:2004-11-10 Published:2005-03-30
  • Contact: JIAN Fang-Fang

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以芳香基三唑类杀菌剂三唑酮为先导物设计并合成了5个含N,N-二烷基二硫代氨基甲酸酯的芳香三唑类化合物, 通过元素分析、红外光谱、核磁共振氢谱和质谱对其结构进行了表征. 用X射线单晶衍射测定了[α-(4-甲氧基苯甲酰基)-2-(1,2,4-三唑-1-基)]乙基-N,N-二甲基二硫代氨基甲酸酯的晶体结构, 晶体属于三斜晶系, 空间群, 晶胞参数为: a＝0.73482(15) nm, b＝1.1051(2) nm, c＝1.1209(2) nm, α＝90.32(3)°, β＝101.97(3)°, γ＝105.13(3)°, V＝0.8578(3) nm3, Z＝2, Dc＝1.357 g/cm3, F(000)＝368, µ＝0.324 mm－1. 生物测试结果显示这5种有机化合物都具有杀菌性和植物生长调节活性

关键词: N,N-二烷基二硫代氨基甲酸, 1H-1,2,4-三唑, 生物活性, 晶体结构

Five novel 1,2,4-triazole compounds containing N,N-dialkyldithiocarbamate moiety were designed and synthesized. Their structures were identified by means of elemental analysis, IR, 1H NMR and MS spectra. The crystal structure of [α-(4-methoxyphenylcarbonyl)-2-(1,2,4-triazol-1-yl)]ethyl-N,N-dime- thyldithio-carbamate was determined by single-crystal X-ray diffraction analysis. It crystallizes in triclinic system with space group , a＝0.73482(15) nm, b＝1.1051(2) nm, c＝1.1209(2) nm, α＝90.32(3)°, β＝101.97(3)°, γ＝105.13(3)°, V＝0.8578(3) nm3, Z＝2, Dc＝1.357 g/cm3, F(000)＝368, µ＝0.324 mm－1. The result of the biological test showed that the five compounds all have fungicidal and plant growth-regulating activities.

Key words: N,N-dialkyldithiocarbamate, crystal structure, biological ac-tivity, 1,2,4-triazole