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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (10): 1291-1293. 上一篇    下一篇

研究简报

N-(安替比林-4-基)-N'-取代芳甲酰基硫脲的合成及其生物活性

吴玮琳1,2，叶文法*,1，杨曼丽1，汪焱钢1   

  1. (1华中师范大学化学学院 武汉 430079)
    (2怀化医学专科学校 怀化 418000)
  • 收稿日期:2004-12-28 修回日期:2005-04-25 发布日期:2005-10-08
  • 通讯作者: 叶文法

Synthesis and Biological Activity of N-(Antipyrin-4-yl)-N'-arylformyl Thiourea

WU Wei-Lin1,2,YE Wen-Fa*,1,YANG Man-Li1,WANG Yan-Gang1   

  1. (1 College of Chemistry, Central China Normal University, Wuhan 430079)
    (2 Huaihua Medical College, Hunan 418000)
  • Received:2004-12-28 Revised:2005-04-25 Published:2005-10-08
  • Contact: YE Wen-Fa

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合成了12个含安替比林基的取代芳甲酰基硫脲类化合物, 用1H NMR, IR和元素分析确证了它们的结构, 并进行了室内生物活性测试. 生测实验证明部分酰基硫脲类化合物, 比如N-(安替比林-4-基)-N'-m(或o)-甲苯甲酰基硫脲, N-(安替比林-4-基)-N-o-硝基苯甲酰基硫脲, N-(安替比林-4-基)-N'-m(或p)-氯苯甲酰基硫脲, 具有一定的细胞分裂素活性.

关键词: 4-氨基安替比林, 细胞分裂素, 酰基硫脲, 生物活性, 合成

Twelve N-(antipyrin-4-yl)-N'-arylformyl thiourea compounds have been synthesized. Their structures were determined by 1H NMR, IR spectra and elemental analysis. The biological activity tests show that some target compounds, for example, N-(antipyrin-4-yl)-N'-m(or-o)-methylphenylformyl thiourea, N-(antipyrin-4-yl)-N'-o-nitrophenylformyl thiourea and N-(antipyrin-4-yl)-N'-m(or-p)-chlorophenylformyl thiourea, have certain ac-tivity of cytokinin.

Key words: acylthiourea, 4-aminoantipyrine, synthesis, cytokinin, biological activity