以2-氨基-5-取代苯基-1,3,4噻二唑和2,6-二氟苯甲酰异氰酸酯为起始原料，合成了10个未见文献报道的含1,3,4-噻二唑环的芳酰基脲类衍生物。通过1H NMR，IR，ESI-MS和元素分析确定化合物的结构。初步生物活性测试表明，此类化合物具有一定的杀虫活性，其中化合物3d (3,5-(CH3)2)和3g (4-C4H9)对蚕豆蚜的杀虫死亡率达到90%以上.

Ten novel benzoyl ureas containing a 1,3,4-thiadiazole group were synthesized by the reaction of 2-amino-5-substituted phenyl-1,3,4-thiadiazole and 2,6-difluorobenzoyl isocyanate，and structurally con-firmed by 1H NMR，IR，ESI-MS techniques and elemental analysis。Preliminary bioassay test indicated that some compounds showed insecticidal activity。Compounds 3d (3,5-(CH3)2) and 3g (4-C4H9) exhibit good insecticidal activity against Aphis craccivora with higer than 90% mortality.

2007年度江苏省高技术研究计划(农业) (NO.BG2007329)和南京工业大学博士创新基金(NO.BSCX200717)