有机化学 ›› 2013, Vol. 33 ›› Issue (11): 2396-2401.DOI: 10.6023/cjoc201305024 上一篇    下一篇

研究论文

含1-甲基环己基的酰基硫脲类化合物合成及除草活性

贡云芸, 黄伟, 刘幸海, 翁建全, 谭成侠   

  1. 浙江工业大学化学工程与材料学院 杭州 310014
  • 收稿日期:2013-05-14 修回日期:2013-06-27 出版日期:2013-11-25 发布日期:2013-07-10
  • 通讯作者: 谭成侠 E-mail:tanchengxia@zjut.edu.cn
  • 基金资助:

    “十二五”国家科技支撑计划(No. 2011BAE06B03-01)资助项目.

Synthesis and Herbicidal Activities of 1-Methylcyclohexyl-formayl Thioureas

Gong Yunyun, Huang Wei, Liu Xinghai, Weng Jianquan, Tan Chengxia   

  1. College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014
  • Received:2013-05-14 Revised:2013-06-27 Online:2013-11-25 Published:2013-07-10
  • Supported by:

    Project supported by the The Twelfth Five-Year National Key Technology R & D Project (No. 2011BAE06B03-01).

为寻求具有较高生物活性的农药先导,以1-甲基环己基酰基为活性基团,与不同的取代胺进行缩合反应,合成了24个未曾报道的1-甲基环己基酰基硫脲类化合物,通过MS,1H NMR,元素分析对其结构进行了表征,并对目标产物进行了初步的生物活性测定. 结果表明,在剂量为200 mg/L时,大部分化合物均表现出较高的除草活性.

关键词: 1-甲基环己基, 酰基硫脲, 合成, 除草活性

In order to find out novel pesticide lead compounds with good biological activity, totally 24 novel 1-methylcyclo-hexyl-formyl thiourea compounds were synthesized by the reaction of 1-methylcyclohexane-carbonyl chloride with various substituted amines. Their structures were confirmed by 1H NMR, MS, and elemental analysis. The biological activities of these compounds were evaluated. Most of the compounds showed good herbicide activities at the concentration of 200 mg/L.

Key words: 1-methylcyclohexyl, acyl thiourea, synthesis, herbicidal activity