三聚氯氰促进的咪唑并[1,2-a]吡啶类化合物的合成

doi:10.6023/cjoc201307004

摘要/Abstract

以三聚氯氰作为反应促进剂，在室温和CH₃CN作为溶剂的条件下，利用取代2-氨基吡啶、醛和烷基异腈三组分缩合，高收率地实现了一系列咪唑并[1，2-a]吡啶类化合物的合成. 产物结构经¹H NMR，¹³C NMR和元素分析等进行了表征.

关键词: 咪唑并[1,2-a]吡啶类化合物, 三聚氯氰, Groebcke 反应, 多组分反应, 合成

Cyanuric chloride-promoted synthesis of imidazo[1,2-a]pyridine derivatives was realized in high yields by the reaction of 2-aminopyridines, aldehydes and isonitriles in CH₃CN at room temperature. All products were characterized by ¹H NMR, ¹³C NMR and elemental analysis.

Key words: Imidazo[1,2-a]pyridines, cyanuric chloride, Groebcke reaction, multi-component reaction, synthesis

引用此文

尹志奎, 田拴宝. 三聚氯氰促进的咪唑并[1,2-a]吡啶类化合物的合成[J]. 有机化学, 2014, 34(2): 387-391.

Yin Zhikui, Tian Shuanbao. Cyanuric Chloride-Promoted Synthesis of Imidazo[1,2-a]pyridines[J]. Chin. J. Org. Chem., 2014, 34(2): 387-391.

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