有机化学 ›› 2015, Vol. 35 ›› Issue (9): 1999-2003.DOI: 10.6023/cjoc201503026 上一篇    下一篇

研究简报

异硫氰酸酯的合成改进

李正义, 石嵩, 庄跃, 郑崇谦, 张金龙, 孙小强   

  1. 常州大学石油化工学院 江苏省绿色催化材料与技术重点实验室 常州 213164
  • 收稿日期:2015-03-18 修回日期:2015-04-16 发布日期:2015-05-14
  • 通讯作者: 孙小强 E-mail:sunxiaoqiang@yahoo.com
  • 基金资助:

    国家自然科学基金(No. 21002009)、江苏省高校自然科学研究(Nos. 12KJA150002, 14KJA150002)、江苏省科技(BY2014037-01)和江苏省青蓝工程资助项目.

Improvement of the Synthesis of Isothiocyanates

Li Zhengyi, Shi Song, Zhuang Yue, Zheng Chongqian, Zhang Jinlong, Sun Xiaoqiang   

  1. Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164
  • Received:2015-03-18 Revised:2015-04-16 Published:2015-05-14
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21002009), the Major Program for the Natural Science Research of Jiangsu Colleges and Universities (Nos. 12KJA150002, 14KJA150002), the Scientific and Technological Project of Jiangsu Province (BY2014037-01), and the Qing Lan Project of Jiangsu Province.

以硫代氯甲酸苯酯和伯胺为原料, 无需额外加碱条件下分别通过一步或两步反应实现异硫氰酸酯的合成. 一步合成法对高活性胺底物比较有效, 而两步合成法具有广泛的底物适用范围. 该方法具有环境友好、原料易得、低毒和操作简便等许多优点, 具有很好的工业应用前景.

关键词: 异硫氰酸酯, 硫代氯甲酸苯酯, 伯胺, 合成

Isothiocyanates were prepared from the reactions of phenyl chlorothionoformate and various primary amines vis one-step or two-step process without additional base. The one-step process is good at highly active amines, while two-step approach is suitable for all kinds of amines. This method has many merits such as environment-friendly, easily available raw materials, low toxicity and convenient operation, which has a good application prospect in industry.

Key words: isothiocyanate, phenyl chlorothionoformate, primary amine, synthesis