有机化学 ›› 2015, Vol. 35 ›› Issue (9): 1923-1928.DOI: 10.6023/cjoc201503002 上一篇    下一篇

研究论文

含硅二烃基锡(IV)的2-巯基苯并噻唑配合物的合成、结构及抗癌活性

廖启华a, 林森a, 邓瑞红a, 黄志强a, 邓柯玉b, 严兆华a   

  1. a 南昌大学化学系 南昌 330031;
    b 南昌大学医学院 南昌 330031
  • 收稿日期:2015-03-03 修回日期:2015-05-20 出版日期:2015-09-25 发布日期:2015-05-26
  • 通讯作者: 林森 E-mail:senlin@ncu.edu.cn
  • 基金资助:

    国家自然科学基金(No. 20762006)资助项目.

Synthesis, Characterization and Antitumour Activity of Diorganotin (IV) Complexes Containing Silicon of 2-Mercaptobenzothiazole

Liao Qihuaa, Lin Sena, Deng Ruihonga, Huang Zhiqianga, Deng Keyub, Yan Zhaohuaa   

  1. a Department of Chemistry, Nanchang University, Nanchang 330031;
    b School of Medicine, Nanchang University, Nanchang 330031
  • Received:2015-03-03 Revised:2015-05-20 Online:2015-09-25 Published:2015-05-26
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 20762006).

合成了6个含硅二烃基锡(IV)的2-巯基苯并噻唑配合物R1R2SnL2 (R1=Me3SiCH2, R2=Me3SiCH2或Ph, Cy; R1=EtMe2SiCH2, R2=EtMe2SiCH2或Ph, Cy. LH=2-硫基苯并噻唑), 并通过IR、1H NMR、13C NMR、元素分析和X射线单晶衍射对目标化合物进行结构表征. 结果表明, 配体L以硫醇互变异构体形式与锡原子配位, 形成了以锡为中心的六配位扭曲八面体结构; 生物活性试验的初步结果显示, 含硅二烃基锡(IV)-2-巯基苯并噻唑对肺腺癌细胞(A549)具有较强的体外抗癌活性.

关键词: 二烃基锡, 2-巯基苯并噻唑, 配合物, 合成, 结构, 抗癌活性

Six diorganotin(IV) complexes containing silicon of 2-mercaptobenzothiazole R1R2Sn(L)2 (R1=Me3SiCH2, R2=Me3SiCH2 or Ph, Cy; R1=EtMe2SiCH2, R2=EtMe2SiCH2 or Ph, Cy. LH=2-mercaptobenzothiazole) have been synthesized and characterized by 1H NMR, 13C NMR, IR, elemental analysis and X-ray single-crystal study. The results showed that ligand L acts as thiol tautomerism coordinating with tin atom, and thus the central tin atom was six coordinated in distorted octahedral geometry. The preliminary bioassay tests showed that diorganotin complexes of 2-mercaptobenzothiazole have a good antitumor activity in vitro against A-549.

Key words: diorganotin, 2-mercaptobenzothiazole, complexes, synthesis, structure, antitumour activity