Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (01): 18-35.DOI: 10.6023/cjoc201208016 Previous Articles     Next Articles



徐清, 李强   

  1. 温州大学化学与材料工程学院 温州 325035
  • 收稿日期:2012-08-17 修回日期:2012-09-22 发布日期:2012-10-08
  • 通讯作者: 徐清
  • 基金资助:

    温州大学引进人才科研启动经费、国家自然科学基金(No. 20902070);教育部第40批留学回国人员科研启动金、浙江省自然科学基金(No. Y4100579)和钱江人才计划D类(No. QJD0902004)资助项目.

Recent Advances of Transition Metal-Catalyzed Aerobic Dehydrative Reactions of Alcohols and Amines and Related Researches

Xu Qing, Li Qiang   

  1. College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035
  • Received:2012-08-17 Revised:2012-09-22 Published:2012-10-08
  • Supported by:

    Project supported by the Startup Funding of Wenzhou University, the National Natural Science Foundation of China (No. 20902070), the Scientific Research Foundation for the Returned Overseas Chinese Scholars of State Education Ministry, the Natural Science Foundation of Zhejiang Province (No. Y4100579) and the Qianjiang Talents Program of Zhejiang Province (No. QJD0902004).

In comparison with other methods, transition metal-catalyzed dehydrative N-alkylation of amines and amides with alcohols, commonly known as the borrowing hydrogen or hydrogen autotransfer reactions and the methodology, is a comparatively green and atom-economic method for the synthesis of the useful amine and amide derivatives. Recently, transition metal-catalyzed aerobic dehydrative N-alkylation method has also attracted much attention, for the reactions can be readily conducted under milder and simpler conditions by using the more stable metal catalysts under the air atmosphere. In this review, we summarize the recent advances of transition metal-catalyzed aerobic dehydrative C—N and C=N bond forming reactions of alcohols with amines and amides for the synthesis of the amine and amide derivatives and imines, as well as those of the related aerobic dehydrative C-alkylation reactions. Mechanisms of the above reactions are also discussed.

Key words: transition metal catalysis, alcohols, amine and amide derivatives, N-alkylation reaction, imination reaction, aerobic oxidative reaction, relay race methodology