Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (3): 679-697.DOI: 10.6023/cjoc202110009 Previous Articles     Next Articles



陈运荣, 刘炜, 杨晓瑜*()   

  1. 上海科技大学物质科学与技术学院 上海 201210
  • 收稿日期:2021-10-09 修回日期:2021-11-13 发布日期:2021-11-25
  • 通讯作者: 杨晓瑜
  • 基金资助:
    国家自然科学基金(21901162); 国家自然科学基金(22171186); 上海科技大学启动基金资助项目

Recent Advances in Kinetic Resolution of Tertiary Alcohols

Yunrong Chen, Wei Liu, Xiaoyu Yang()   

  1. School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210
  • Received:2021-10-09 Revised:2021-11-13 Published:2021-11-25
  • Contact: Xiaoyu Yang
  • Supported by:
    National Natural Science Foundation of China(21901162); National Natural Science Foundation of China(22171186); ShanghaiTech University Start-Up Funding

Chiral tertiary alcohol is widely present in a series of bioactive compounds, natural products and pharmaceuticals. Consequently, the development of efficient asymmetric catalytic methods for their syntheses is highly important. Kinetic resolution (KR) is an important strategy to access enantioenriched alcohols from racemic alcohols. However, due to the requirement to distinguish three none-hydrogen substituents at the α-position of tertiary alcohols, it is challenging to develop highly efficient kinetic resolution protocols for tertiary alcohols with broad substrate scope. Nevertheless, significant progress has been made in the field of nonenzymatic kinetic resolution of tertiary alcohols in recent years, and a number of novel asymmetric reactions and catalytic systems have been successfully applied in the KR of tertiary alcohols. The tremendous advances in the kinetic resolution of tertiary alcohols are comprehensively reviewed, the substrate scope, characteristics, mechanisms and limitations of these methods are summarized, and our perspective on this research field is also provided.

Key words: chiral tertiary alcohols, asymmetric catalysis, kinetic resolution