Synthesis and Cytotoxicity of N-Benzylidene Hesperitin Hydrazones and Analogues

doi:10.6023/cjoc201304028

Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (9): 1988-1993.DOI: 10.6023/cjoc201304028 Previous Articles Next Articles

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N-亚苄基橙皮素腙及类似物的合成与细胞活性

刘志平^a,b, 韦万兴^a, 甘春芳^b, 黄燕敏^b, 刘盛^a, 周敏^a, 崔建国^b

a 广西大学化学化工学院南宁 530004;
b 广西师范学院化学与生命科学学院南宁 530001

收稿日期:2013-04-18 修回日期:2013-05-22 发布日期:2013-05-31
通讯作者: 韦万兴 E-mail:chewxwei@yahoo.com.cn
基金资助:
国家自然科学基金(No. 81060261);广西科学自然科学基金重点(No. 2011jjD20002)资助项目

Synthesis and Cytotoxicity of N-Benzylidene Hesperitin Hydrazones and Analogues

Liu Zhiping^a,b, Wei Wanxing^a, Gan Chunfang^b, Huang Yanmin^b, Liu Sheng^a, Zhou Min^a, Cui Jianguo^b

a College of Chemistry and Chemical Engineer, Guangxi University, Nanning 530004;
b College of Chemistry and Life Science, Guangxi Teachers Education University, Nanning 530001

Received:2013-04-18 Revised:2013-05-22 Published:2013-05-31
Supported by:
Project supported by the National Natural Science Foundation of China (No. 81060261) and the Natural Science Foundation of Guangxi Province (No. 2011jjD20002)

Hesperitin hydrazone (2) was generated by the reaction of natural hesperitin (1) as raw material with hydrazine hydrate. Eight N-benzylidene hesperitin hydrazones 3～10 and six analogues 11～16 were synthesized by the reaction of 2 with various aldehydes, respectively. The structures of all reaction products were confirmed by NMR, IR and HR-MS techniques. And the cytotoxity against human cancer cell SGC-7901 of the synthesized compounds was also evaluated. The results showed 5, 7, 10 and 16 exhibiting distinct cytotoxity against SGC-7901.

Key words: hesperitin, hesperitin hydrazones, N-benzylidene, cytotoxicity

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Liu Zhiping, Wei Wanxing, Gan Chunfang, Huang Yanmin, Liu Sheng, Zhou Min, Cui Jianguo. Synthesis and Cytotoxicity of N-Benzylidene Hesperitin Hydrazones and Analogues[J]. Chin. J. Org. Chem., 2013, 33(9): 1988-1993.

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N-亚苄基橙皮素腙及类似物的合成与细胞活性

Synthesis and Cytotoxicity of N-Benzylidene Hesperitin Hydrazones and Analogues

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