A Convenient Preparation Method for 2-Amino-3,5-dinitro-6-chloropyridine and Its Derivatives

doi:10.6023/cjoc201310016

Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (3): 584-588.DOI: 10.6023/cjoc201310016 Previous Articles Next Articles

Articles

一种有效制备2-氨基-3,5-二硝基-6-氯吡啶及其衍生物的方法

马丛明^a, 侯可辉^a, 刘祖亮^a, 姚其正^a,b

a 南京理工大学化工学院南京 210094;
b 中国药科大学药学院南京 210009

收稿日期:2013-10-14 修回日期:2013-11-05 发布日期:2013-11-21
通讯作者: 姚其正 E-mail:qz_yao@163.com
基金资助:
国家自然科学基金（No. 21102125）资助项目.

A Convenient Preparation Method for 2-Amino-3,5-dinitro-6-chloropyridine and Its Derivatives

Ma Congming^a, Hou Kehui^a, Liu Zuliang^a, Yao Qizheng^a,b

a School of Chemical Engineering, Nanjing University of Science &Technology, Nanjing 210094;
b School of Pharmacy, China Pharmaceutical University, Nanjing 210009

Received:2013-10-14 Revised:2013-11-05 Published:2013-11-21
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21102125).

1. A Convenient Preparation Method for 2-Amino-3,5-dinitro-6-chloropyridine and Its Derivatives.PDF(404KB)

Abstract

A novel preparation method for 2-amino-3,5-dinitro-6-chloropyridine (4) and its derivatives was described starting from cheap and easily available 2,6-dichloropyridine (1). Compound 4 was obtained by nitration, amination and again nitration reaction, followed by reacting with several nucleophilic reagents, such as ammonia, sodium azide to form 2-amino-3,5-dinitropyridine-6-substituted derivatives 5～7, respectively. The results showed that this synthetic route had the advantages of easy-obtained raw materials, simple work-up and high purity product.

Key words: preparation, 2,6-dichloropyridine, 2-amino-3,5-dinitro-6-chloropyridine, nucleophilic substitution

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Ma Congming, Hou Kehui, Liu Zuliang, Yao Qizheng. A Convenient Preparation Method for 2-Amino-3,5-dinitro-6-chloropyridine and Its Derivatives[J]. Chin. J. Org. Chem., 2014, 34(3): 584-588.

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一种有效制备2-氨基-3,5-二硝基-6-氯吡啶及其衍生物的方法

A Convenient Preparation Method for 2-Amino-3,5-dinitro-6-chloropyridine and Its Derivatives

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