Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (5): 1257-1265.DOI: 10.6023/cjoc201911036 Previous Articles     Next Articles


张顺吉, 刘会丽   

  1. 淮北师范大学化学与材料科学学院 安徽淮北 235000
  • 收稿日期:2019-11-27 修回日期:2020-01-06 发布日期:2020-01-21
  • 通讯作者: 张顺吉

Sulfuric Acid Catalyzed Rapid Nucleophilic Substitution of Propargyl Alcohols

Zhang Shunji, Liu Huili   

  1. Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000
  • Received:2019-11-27 Revised:2020-01-06 Published:2020-01-21

Sulfuric acid efficiently catalyzes the direct substitution of the hydroxyl group of propargylic alcohols with a variety of C- and O-based nucleophiles to aid C-C and C-O bond formation. The reactions can be performed in an undried solvent under air atmosphere to obtain the desired products in good yields. In most cases, the reaction proceeds to completion in 1 min at room temperature.

Key words: sulfuric acid, catalyzed, propargyl alcohols, nucleophilic substitution