Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (8): 1682-1686.DOI: 10.6023/cjoc201402001 Previous Articles     Next Articles



张梅梅a, 刘蕴b, 王香善a,b   

  1. a 江苏省药用植物生物技术重点实验室 江苏师范大学 徐州 221116;
    b 江苏师范大学化学化工学院 徐州 221116
  • 收稿日期:2014-02-01 修回日期:2014-04-01 发布日期:2014-04-16
  • 通讯作者: 王香善
  • 基金资助:


Synthesis of 2-Phenyl-2-benzoylquinazolin-4(1H)-one Derivatives in Ionic Liquids Catalyzed by Iodine

Zhang Meimeia, Liu Yunb, Wang Xiangshana,b   

  1. a Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Jiangsu Normal University, Xuzhou 221116;
    b School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116
  • Received:2014-02-01 Revised:2014-04-01 Published:2014-04-16
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 20802061) and the College Industrialization Project of Jiangsu Province (No. JHB2012-31).

A green method for the synthesis of 2,3-dihydro-2-benzoyl-2-phenylquinazolin-4(1H)-one derivatives, is described in high yields using ionic liquids as green media. The method involves a reaction of 2-aminobenzamide and benzil catalyzed by iodine. The structure of the product 2-benzoyl-3-phenethyl-2-phenyl-2,3-dihydroquinazolin-4(1H)-one (3f) was confirmed by X-ray diffraction analysis.

Key words: quinazolin-4(1H)-one, 2-aminobenzamide, benzil, ionic liquid, iodine