Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (1): 55-69.DOI: 10.6023/cjoc201407032 Previous Articles     Next Articles



赵蔚a, 刘伟b   

  1. a 天津科技大学材料科学与化学工程学院 天津 300457;
    b 天津科技大学理学院 天津 300457
  • 收稿日期:2014-07-19 修回日期:2014-08-28 发布日期:2014-09-16
  • 通讯作者: 刘伟
  • 基金资助:

    国家自然科学基金(No. 21302139)资助项目.

Progresses of Weinreb Amides in Organic Synthesis

Zhao Weia, Liu Weib   

  1. a College of Sciences, Tianjin University of Science & Technology, Tianjin 300457;
    b College of Material Science and Chemical Engineering, Tianjin 300457
  • Received:2014-07-19 Revised:2014-08-28 Published:2014-09-16
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21302139).

N-Methoxy-N-methylamides, now popularly called Weinreb amides (WAs) after their discovery, have surfaced as amides with a difference. This amide has served as an excellent acylating agent for organolithium or organomagnesium reagents and as an effective equivalent for an aldehyde group. These two aspects have been exploited exhaustively in many synthetic strategies. The growing synthetic utility and preparation of the Weinreb amides are reviewed.

Key words: Weinreb amides, building block, equivalents, aldehydes, ketones, Grignard agent