Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (2): 384-389.DOI: 10.6023/cjoc201409028 Previous Articles     Next Articles



严楠a,b, 熊云奎b, 夏剑辉b, 芮培欣b, 雷志伟a, 廖维林a, 熊斌a,b   

  1. a 国家单糖化学合成工程技术研究中心 南昌 330027;
    b 江西师范大学化工研发中心 南昌 330027
  • 收稿日期:2014-09-13 修回日期:2014-11-13 发布日期:2014-11-21
  • 通讯作者: 严楠
  • 基金资助:

    国家科技支撑计划(No. 2009BAI75B02)、江西省研究生创新基金(No. YC2014-B030)、江西师范大学优秀博士论文培育计划资助项目.

Green Synthesis of Novel Spirooxindole Derivatives in Deep Eutectic Solvent

Yan Nana,b, Xiong Yunkuib, Xia Jianhuib, Rui Peixinb, Lei Zhiweia, Liao Weilina, Xiong Bina,b   

  1. a National Monosaccharide Chemical Synthesis Engineering Research Center, Nanchang 330027;
    b Chemical Research and Development Center, Jiangxi Normal University, Nanchang 330027
  • Received:2014-09-13 Revised:2014-11-13 Published:2014-11-21
  • Supported by:

    Project supported by the National Science and Technology Support Program of China (No. 2009BAI75B02), the Innovation Fund Designated for Graduate Students of Jiangxi Province (No. YC2014-B030), and the Outstanding Doctoral Dissertation Cultivation Program of Jiangxi Normal University.

A series of novel spirooxindole derivatives were synthesized by three-component domino Knoevenagel-Michael reaction between aldehydes, indole and 6,10-dioxaspiro[4.5]decane-7,9-dione using the deep eutectic solvent (DES) choline chloride-oxalic acid as a catalyst in 70%~97% yields. This method has some distinct advantages such as easy work-up, mild reaction conditions, short reaction time, environmental friendliness and accessibility of catalyst.

Key words: deep eutectic solvent, domino reaction, spirooxindole derivatives, green synthesis