Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (5): 1173-1178.DOI: 10.6023/cjoc201411012 Previous Articles     Next Articles



杨国玉, 王彩霞, 樊素芳, 谢普会, 金秋, 徐翠莲   

  1. 河南农业大学理学院 郑州 450002
  • 收稿日期:2014-11-08 修回日期:2014-12-13 发布日期:2015-01-06
  • 通讯作者: 徐翠莲
  • 基金资助:


Microwave Assisted Solvent-Free Synthesis of 3-(Trifluoroacetyl)coumarins

Yang Guoyu, Wang Caixi, Fan Sufang, Xie Puhui, Jin Qiu, Xu Cuilian   

  1. College of Sciences, Henan Agricultural University, Zhengzhou 450002
  • Received:2014-11-08 Revised:2014-12-13 Published:2015-01-06
  • Supported by:

    Project supported by the Education Foundation of Henan Province (Nos.2009A150012, 2011A210018), the National Natural Science Foundation of China (No.21102037), and the Key Science and Technology Foundation of Henan Province (No.112101110200).

A series of 3-(trifluoroacetyl)coumarins were synthesized by recyclization of ethyl-2-hydroxy-2-trifluoromethyl-2H-chromene-3-carboxylates under microwave assisted solvent-free conditions. This method has the advantages of short reaction time, high yields (73%~88%), easy operation and environmental friendliness. The synthesized compounds were characterized by IR, NMR, HRMS and X-ray studies.

Key words: microwave, 3-(trifluoroacetyl)coumarins, recyclization, solvent-free