Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (3): 539-555.DOI: 10.6023/cjoc201412050 Previous Articles     Next Articles



胡志勇a, 童晓峰a, 刘桂霞b   

  1. a 华东理工大学 教育部结构可控先进功能材料及其制备重点实验室 上海 200237;
    b 中国科学院上海有机化学研究所 金属有机化学国家重点实验室 上海 200032
  • 收稿日期:2014-12-30 修回日期:2015-02-13 发布日期:2015-02-14
  • 通讯作者: 童晓峰, 刘桂霞;
  • 基金资助:

    国家自然科学基金(No. 21202184)资助项目.

C—H Functionalization Induced by the Oxidizing Directing Group

Hu Zhiyonga, Tong Xiaofenga, Liu Guixiab   

  1. a Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237;
    b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • Received:2014-12-30 Revised:2015-02-13 Published:2015-02-14
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21202184).

Transition-metal catalyzed C—H functionalization is a straightforward and efficient way to construct C—C and C—X bonds. However, these transformations usually require stioichiometric or excess amount of external oxidants to oxidize low valent metal and regenerate the active catalytic species. The use of the oxidizing directing group, which contains some special group acting as the internal oxidant, can avoid the troubles arousing from the external oxidants and make the reaction process more simple and efficient. Recently, increasing number of novel oxidizing directing groups have been designed and diverse kinds of reactions have been developed. This approach can be used to synthesize kinds of heterocyles or highly functionalized products under external oxidant free conditions.

Key words: C—H fucntionalization, oxidizing directing group, internal oxidant, transition metal