Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (3): 556-569.DOI: 10.6023/cjoc201501017 Previous Articles     Next Articles



张柯a, 徐修华b, 卿凤翎a,b   

  1. a 东华大学化学化工与生物工程学院 上海 201620;
    b 中国科学院上海有机化学研究所 有机氟化学重点实验室 上海 200032
  • 收稿日期:2015-01-14 修回日期:2015-02-09 发布日期:2015-02-12
  • 通讯作者: 卿凤翎
  • 基金资助:

    国家自然科学基金(Nos. 21421002, 21332010, 21272036)和国家重点基础研究发展计划(No. 2012CB21600)资助项目.

Recent Advances of Direct Trifluoromethylthiolation

Zhang Kea, Xu Xiuhuab, Qing Fenglinga,b   

  1. a College of Chemistry, Chemical Engineering and Biotechology, Donghua University, Shanghai 201620;
    b Key laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • Received:2015-01-14 Revised:2015-02-09 Published:2015-02-12
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21421002, 21332010, 21272036) and the National Basic Research Program of China (No. 2012CB21600).

Compounds containing trifluoromethylthio group (SCF3) play an important role in pharmaceuticals, agrochemicals and materials due to its strong electron-withdrawing effect and extremely high lipophilicity. Very recently, trifluoromethylthiolation has received a great attention. In this review, the new progress of direct trifluoromethylthiolation is described. Furthermore, the synthetic challenge for trifluoromethylthiolation is also discussed.

Key words: trifluoromethylthiolation, organofluorine chemistry, oxidative coupling