Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (9): 1820-1833.DOI: 10.6023/cjoc201503007 Previous Articles     Next Articles



张文曼, 戴建军, 许华建   

  1. 合肥工业大学医学工程学院 合肥 230009
  • 收稿日期:2015-03-04 修回日期:2015-05-28 发布日期:2015-06-04
  • 通讯作者: 戴建军, 许华建;
  • 基金资助:

    国家自然科学基金(Nos. 21472033, 21402036, 21272050)、中国博士后科学基金(No. 2014M551793)和中央高校基本科研业务费专项资金(No. 2013HGBH0046)资助项目.

Recent Advances of Transition Metal-Catalyzed C(sp3)—C(sp3) Cross-Coupling Reactions of Non-activated Alkyl Halides

Zhang Wenman, Dai Jianjun, Xu Huajian   

  1. School of Medical Engineering, Hefei University of Technology, Hefei 230009
  • Received:2015-03-04 Revised:2015-05-28 Published:2015-06-04
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21472033, 21402036, 21272050), the China Postdoctoral Science Foundation (No. 2014M551793), and the Fundamental Research Funds for the Central Universities (No. 2013HGBH0046).

Recently, great attention has been directed to the transition-metal-catalyzed cross-coupling reactions of non-acti-vated alkyl halides for the construction of C(sp3)—C(sp3) bonds. However, due to the difficulty of oxidative addition of the non-activated alkyl halides with a metal catalyst and the resulting metal-alkyl intermediate prone to β-H elimination, the cross-coupling of non-activated alkyl halides with alkyl nucleophiles remains a challenge. This review summarizes the recent advances of C(sp3)—C(sp3) cross-coupling of non-activated alkyl halides catalyzed by transition-metals.

Key words: transition-metal, catalyze, non-activated alkyl halide, cross-coupling, advance