Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (9): 1981-1984.DOI: 10.6023/cjoc201505007 Previous Articles     Next Articles



刘艳萍a, 黄丽刚a, 汪晓翠a, 文成全a, 许莎莎a, 宋小平a, 韩长日a, 陈光英a,b, 付艳辉a   

  1. a 海南师范大学热带药用植物化学教育部重点实验室 海口 571158;
    b 海南师范大学化学与化工学院 海口 571158
  • 收稿日期:2015-05-05 修回日期:2015-05-25 发布日期:2015-05-29
  • 通讯作者: 陈光英, 付艳辉;
  • 基金资助:

    国家自然科学基金(Nos. 31360069, 21302181)、海南省自然科学基金(No. 214027)、国际科技合作与交流专项(No. 2014DFA40850)、海南省应用技术研发与示范推广专项(No. ZDXM2015063)、海南省高校科研(No. HNKY2014-41)和国家大学生创新训练计划(Nos. 201411658031, 3010151053)资助项目.

A New Polyoxygenated Seco-cyclohexene Derivative from Artabotrys pilosus

Liu Yanpinga, Huang Liganga, Wang Xiaocuia, Wen Chenquana, Xu Shashaa, Song Xiaopinga, Han Changria, Chen Guangyinga,b, Fu Yanhuia   

  1. a Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158;
    b College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
  • Received:2015-05-05 Revised:2015-05-25 Published:2015-05-29
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 31360069, 21162009), the Natural Science Foundation of Hainan Province (No. 214027), the International S&T Cooperation Program of China (No. 2014DFA40850), the Major Technology Project of Hainan (No. ZDXM2015063), the Scientific Research Project of Hainan Colleges and Universities (No. HNKY2014-41) and the National Undergraduate Innovation Training Programs (Nos. 201411658031, 3010151053).

A new polyoxygenated seco-cyclohexene derivative, artapilosol A (1), together with two known polyoxygenated seco-cyclohexene derivatives, microcarpin A (2) and uvarisubol B (3), was isolated from the stems and leaves of Artabotrys pilosus. Their structures were established on the basis of extensive spectral data. This is the first report that polyoxygenated seco-cyclohexene derivatives were isolated from the genus Artabotrys. Cytotoxicities of compounds 1~3 were tested against five cancer cell lines (HL-60, A549, SMMC-7721, MCF-7 and SW480). Results showed that compounds 1~3 exhibited significant inhibitory effects with IC50 values comparable to those of cisplatin.

Key words: Artabotrys, Artabotrys pilosus, artapilosol A, cytotoxicity