Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (1): 222-228.DOI: 10.6023/cjoc201507011 Previous Articles     Next Articles



冯俊, 阿布拉江·克依木, 马夏冰, 李文博, 麦麦提艾力·奥布力   

  1. 新疆大学化学化工学院 新疆石油天然气精细化工教育部&自治区重点实验室 乌鲁木齐 830046
  • 收稿日期:2015-07-15 修回日期:2015-08-29 发布日期:2015-09-06
  • 通讯作者: 阿布拉江·克依木
  • 基金资助:

    新疆教育部研究生科研创新项目基金(No. XJGRI2014019)、国家自然科学基金(No. 21462041)和新疆维吾尔自治区天山英才培养计划资助项目.

Multi-Component One-Pot Reactions for the Synthesis ofSpirooxindole-pyrano[2,3-c]pyrazole Derivatives

Feng Jun, Ablajan Keyume, Ma Xiabing, Li Wenbo, Obul Mamateli   

  1. Key Laboratory of Oil & Gas Fine Chemicals, Ministry of Education & Xinjiang Uyghur Autonomous Region, College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046
  • Received:2015-07-15 Revised:2015-08-29 Published:2015-09-06
  • Supported by:

    Project supported by the Graduate Student Research Innovation Project of Xinjiang Educational Department (No. XJGRI2014019), the National Natural Science Foundation of China (No. 21462041), and the Tianshan Talent Cultivation Project of Xinjiang Uyghur Autonomous Region.

A highly efficient strategy for the one-pot synthesis of multi-substituted spirooxindol-pyrano[2,3-c]pyrazole derivatives was developed. The product formed in good yield from the reaction of acetylenedicarboxylate, hydrazine, isatin, and (E)-1-methylthio-1-methylamino-2-nitroethylene in the presence of Et3N catalyst. This simple and convenient method could also be used to prepare similar types of product.

Key words: spirooxindole, multi-component reaction, one-pot synthesis, pyrano[2,3-c]pyrazole