Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (5): 1099-1103.DOI: 10.6023/cjoc201510009 Previous Articles     Next Articles



许招会a, 周鹏b, 刘德永a   

  1. a. 江西师范大学化学化工学院 南昌 330022;
    b. 南昌理工学院新能源与环境工程学院 南昌 330029
  • 收稿日期:2015-10-10 修回日期:2015-12-03 发布日期:2016-01-21
  • 通讯作者: 许招会
  • 基金资助:


Efficient One-Pot Synthesis of 3,3-Dimethyl-diphenyl-2,4-dioxa-8,10-diazaspiro[5.5]undecane-1,5-dione-9-thione Derivatives

Xu Zhaohuia, Zhou Pengb, Liu Deyonga   

  1. a. College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022;
    b. School of New Energy and Enviroment Engineering, Nanchang Institute of Technology, Nanchang 330029
  • Received:2015-10-10 Revised:2015-12-03 Published:2016-01-21
  • Supported by:

    Project supported by the National Science and Technology Project (No. 2001BA323C) and the Graduate Innovation Foundation of Jiangxi Province (No. YC2015-B023).

Six kinds of 3,3-dimethyl-diphenyl-2,4-dioxa-8,10-diazaspiro[5.5]-undecane-1,5-dione-9-thione derivatives were sythesized by the three component one-pot reaction of aromatic aldehydes with thiourea and 2,2-dimethyl-1,3-dio-xane-4,6-dione in the presence of molecular iodine under solvent-free conditions. The results indicated that the yields ranged from 73% to 91% at 80 ℃ for 3.0~6.0 h using 10 mol% iodine (relative to the substrate of 2,2-dimethyl-1,3-dioxane-4,6-dione). Furthermore, the present procedure with high yields was milder conditions and simpler post-treatment process.

Key words: molecular iodine, solvent-free, three component condensation reaction, spiro hetrobicyclic compounds