Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (3): 502-511.DOI: 10.6023/cjoc201510033 Previous Articles     Next Articles



周红艳a, 李娜娜b, 杨靖亚b, 李天媛b, 李政b   

  1. a 甘肃农业大学理学院 兰州 730070;
    b 西北师范大学化学化工学院 兰州 730070
  • 收稿日期:2015-10-28 修回日期:2015-11-25 发布日期:2015-12-04
  • 通讯作者: 周红艳, 杨靖亚;
  • 基金资助:

    国家自然科学基金(Nos. 21362034, 21462038)、高等学校博士学科点专项科研基金(No. 20136203120005)、甘肃省高等学校科研(No. 2013B-003)和甘肃农业大学科技创新基金(No. GAU-CX1115)资助项目.

Advance in Catalytic Asymmetric Conjugate Cyanation

Zhou Hongyana, Li Nanab, Yang Jingyab, Li Tianyuanb, Li Zhengb   

  1. a College of Science, Gansu Agricultural University, Lanzhou 730070;
    b College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070
  • Received:2015-10-28 Revised:2015-11-25 Published:2015-12-04
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21362034, 21462038), the Research Fund for the Doctoral Program of Higher Education of China (No. 20136203120005), the University Scientific Research Project of Gansu Province (No. 2013B-003) and the Science and Technology Innovation Fund of Gansu Agricultural University (No. GAU-CX1115).

As one of the most important methods to construct C—C bond in enantioselective manner and afford optically active β-cyano compounds, catalytic asymmetric conjugate cyanation reaction has attracted much attentions worldwide since the first report in 2003. Over the past decade, some important achievements have been made in the catalytic asymmetric conjugate cyanation of α,β-unsaturated imides, α,β-unsaturated N-acylpyrroles, α,β-unsaturated ketones, α,β-unsaturated esters, and nitroalkenes. The research progress in this field is reviewed from both metal catalysis and organocatalysis based on different Michael acceptors.

Key words: asymmetric catalysis, cyanation, Michael addition, α,β-unsaturated compounds, transition metals, organocatalysis