Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (6): 1963-1976.DOI: 10.6023/cjoc202212024 Previous Articles     Next Articles


罗诚a,b, 尹艳丽a,b,*(), 江智勇b,*()   

  1. a 河南工业大学前沿交叉科学与技术学院 生物工程学院 郑州 450001
    b 河南师范大学化学化工学院 河南新乡 475004
  • 收稿日期:2022-12-17 修回日期:2023-01-09 发布日期:2023-01-18
  • 基金资助:
    国家自然科学基金(22171072); 国家自然科学基金(21925103)

Recent Advances in Asymmetric Synthesis of P-Chiral Phosphine Oxides

Cheng Luoa,b, Yanli Yina,b,*(), Zhiyong Jiangb,*()   

  1. a College of Bioengineering, College of Advanced Interdisciplinary Science and Technology, Henan University of Technology, Zhengzhou 450001
    b School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007
  • Received:2022-12-17 Revised:2023-01-09 Published:2023-01-18
  • Contact: E-mail:;
  • Supported by:
    National Natural Science Foundation of China(22171072); National Natural Science Foundation of China(21925103)

Enantioenriched organophosphates are ubiquitous in a large array of chiral ligands, chiral catalysts and bioactive molecules. Over the past few decades, synthetic chemists have contributed substantial efforts to develop the efficient methodologies for the construction of P-chiral phosphine derivatives, considerably enriching the arsenal of chiral organophosphine ligands and the promising pharmaceutical molecules. Among them, a number of works are focused on the synthesis of P-chiral phosphine oxides because it is more stability than trivalent phosphines and the convenient reduction. In view of the rapid progress in this area and the currently available reviews, the progress in the last three years is summarized and discussed, namely from 2020 to 2022. The description of the synthetic strategy is divided into five segments, involving asymmetric induction, catalytic desymmetrization, catalytic asymmetric synthesis, catalytic kinetic resolution or dynamic kinetic asymmetric transformation, and enzyme catalysis.

Key words: P-chiral phosphine oxides, organic phosphine ligands, asymmetric synthesis, asymmetric catalysis, kinetic resolution