Chinese Journal of Organic Chemistry ›› 2024, Vol. 44 ›› Issue (2): 448-480.DOI: 10.6023/cjoc202308023 Previous Articles     Next Articles



杨爽*(), 房新强*()   

  1. 中国科学院大学福建物质结构研究所 结构化学重点实验室 煤制乙二醇重点实验室和分子合成卓越中心 福州 350100
  • 收稿日期:2023-08-25 修回日期:2023-09-30 发布日期:2023-10-23
  • 基金资助:
    国家自然科学基金(22071242); 国家自然科学基金(21871260); 中国科学院战略重点研究方案(XDB20000000); 福建省自然科学基金(2021J01522)

Kinetic Resolutions Enabled by N-Heterocyclic Carbene Catalysis: An Update

Shuang Yang(), Xinqiang Fang()   

  1. State Key Laboratory of Structural Chemistry, and Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, University of Chinese Academy of Sciences, Fuzhou 350100
  • Received:2023-08-25 Revised:2023-09-30 Published:2023-10-23
  • Contact:;
  • Supported by:
    National Natural Science Foundation of China(22071242); National Natural Science Foundation of China(21871260); Strategic Priority Research Program of the Chinese Academy of Sciences(XDB20000000); Fujian Provincial Natural Science Foundation(2021J01522)

Kinetic resolution is one of the most commonly used methods allowing access to enantioenriched compounds. The last two decades have seen the rapid development of kinetic resolutions enabled by N-heterocyclic carbene catalysis, and part of the achievements have been summarized in our previous review paper published in 2017. Since then, a series of new advances have been realized, and this review will provide an update of this field covering reports from mid-2017 to 2023.

Key words: kinetic resolution, N-heterocyclic carbene, asymmetric catalysis, racemates, enantioenriched compounds