Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (7): 1681-1685.DOI: 10.6023/cjoc201601034 Previous Articles     Next Articles



赵玉英a, 王二兵a, 王颖莉b   

  1. a. 太原科技大学化学与生物工程学院 太原 030021;
    b. 山西中医学院中药药理学系 太原 030024
  • 收稿日期:2016-01-27 修回日期:2016-02-26 发布日期:2016-03-18
  • 通讯作者: 赵玉英
  • 基金资助:


Tetra-butyl Ammonium Iodide-Catalyzed Oxidative Dehydrogenation for the Selective Synthesis of Z-β-Acylamino Enones

Zhao Yuyinga, Wang Erbinga, Wang Yinglib   

  1. a. Institute of Chemical and Biological Technology, Taiyuan University of Science and Technology, Taiyuan 030021;
    b. Department of Traditional Chinese Pharmacology, Shanxi University of Traditional Chinese Medicine, Taiyuan 030024
  • Received:2016-01-27 Revised:2016-02-26 Published:2016-03-18
  • Supported by:

    Project supported by the Science and Technology Key Project of Shanxi Province (No. 20130313015-2).

A tetra-butyl ammonium iodide (TBAI)-catalyzed oxidative dehydrogenation of β-acylamino ketones for the synthesis of Z-β-acylamino enones has been developed. The present method has some distinct advantages such as mild conditions, high selectivity, readily available starting materials, and broad substrate scope. This method is also the first example of oxidative dehydrogenation with the use of TBAI/TBHP (tert-butyl hydroperoxide) oxidation system.

Key words: iodide, catalytic dehydrogenation, β-acylamino enones, stereoselectivity