Synthesis and Cytotoxicity of Azasugar Modified Anthraquinone Derivatives

doi:10.6023/cjoc201602012

Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (8): 1921-1925.DOI: 10.6023/cjoc201602012 Previous Articles Next Articles

NOTE

氮杂糖修饰的蒽醌衍生物的合成及细胞毒性

张平竹, 魏笑, 刘欢, 王齐伟, 马趁, 戎瑞雪, 李小六

河北大学化学与环境科学学院河北省化学生物学重点实验室保定 071002

收稿日期:2016-02-16 修回日期:2016-04-26 发布日期:2016-05-03
通讯作者: 李小六 E-mail:lixl@hbu.cn
基金资助:
国家自然科学基金（Nos. 21172051，21372059）资助项目.

Synthesis and Cytotoxicity of Azasugar Modified Anthraquinone Derivatives

Zhang Pingzhu, Wei Xiao, Liu Huan, Wang Qiwei, Ma Chen, Rong Ruixue, Li Xiaoliu

Key Laboratory of Chemical Biology of Hebei Province, School of Chemistry and Environmental Science, Hebei University, Baoding 071002

Received:2016-02-16 Revised:2016-04-26 Published:2016-05-03
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21172051, 21372059).

1. Synthesis and Cytotoxicity of Azasugar Modified Anthraquinone Derivatives.PDF(599KB)

Abstract

In order to develop the anti-tumor agents with high efficiency and low toxicity, a series of novel azasugar modified anthraquinone derivatives have been designed and synthesized by the ammonolysis of N-alkylamino azasugar with rhine and microwave assisted Ullmann coupling reaction of N-alkylamino azasugar with 1-amino-4-bromoanthraquinone-2-sulfonic acid. Their cytotoxic activities against Hela, A549, MCF-7 and MGC-803 cells were preliminarily evaluated.

Key words: anthraquinone, rhein, azasugar, Ullmann coupling, cytotoxicity

Cite this article

Zhang Pingzhu, Wei Xiao, Liu Huan, Wang Qiwei, Ma Chen, Rong Ruixue, Li Xiaoliu. Synthesis and Cytotoxicity of Azasugar Modified Anthraquinone Derivatives[J]. Chin. J. Org. Chem., 2016, 36(8): 1921-1925.

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氮杂糖修饰的蒽醌衍生物的合成及细胞毒性

Synthesis and Cytotoxicity of Azasugar Modified Anthraquinone Derivatives

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