Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (8): 1921-1925.DOI: 10.6023/cjoc201602012 Previous Articles     Next Articles



张平竹, 魏笑, 刘欢, 王齐伟, 马趁, 戎瑞雪, 李小六   

  1. 河北大学化学与环境科学学院 河北省化学生物学重点实验室 保定 071002
  • 收稿日期:2016-02-16 修回日期:2016-04-26 发布日期:2016-05-03
  • 通讯作者: 李小六
  • 基金资助:

    国家自然科学基金(Nos. 21172051,21372059)资助项目.

Synthesis and Cytotoxicity of Azasugar Modified Anthraquinone Derivatives

Zhang Pingzhu, Wei Xiao, Liu Huan, Wang Qiwei, Ma Chen, Rong Ruixue, Li Xiaoliu   

  1. Key Laboratory of Chemical Biology of Hebei Province, School of Chemistry and Environmental Science, Hebei University, Baoding 071002
  • Received:2016-02-16 Revised:2016-04-26 Published:2016-05-03
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21172051, 21372059).

In order to develop the anti-tumor agents with high efficiency and low toxicity, a series of novel azasugar modified anthraquinone derivatives have been designed and synthesized by the ammonolysis of N-alkylamino azasugar with rhine and microwave assisted Ullmann coupling reaction of N-alkylamino azasugar with 1-amino-4-bromoanthraquinone-2-sulfonic acid. Their cytotoxic activities against Hela, A549, MCF-7 and MGC-803 cells were preliminarily evaluated.

Key words: anthraquinone, rhein, azasugar, Ullmann coupling, cytotoxicity