Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (7): 1447-1464.DOI: 10.6023/cjoc201603030 Previous Articles     Next Articles



耿谦a, 李子宁a, 吕哲a, 梁广鑫a,b   

  1. a. 南开大学 元素有机化学国家重点实验室 天津 300071;
    b. 天津化学化工协同创新中心 天津 300071
  • 收稿日期:2016-03-17 修回日期:2016-04-27 发布日期:2016-05-06
  • 通讯作者: 梁广鑫
  • 基金资助:


Progress in Total Syntheses of Leuconolam- Leuconoxine-Mersicarpine Alkaloids

Geng Qiana, Li Zininga, Lü Zhea, Liang Guangxina,b   

  1. a. State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071;
    b. Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071
  • Received:2016-03-17 Revised:2016-04-27 Published:2016-05-06
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21372127, 21572104) and the Program for New Century Excellent Talents in University.

Leuconolam-leuconoxine-mersicarpine monoterpene indole alkaloids are mainly isolated from Apocynaceae Kopsia species of plant. Though sharing the same biogenetic origin, they are a family of natural products showing incredible structural complexity and diversity. Moreover, many of them exhibit excellent bioactivities, for example, anti-inflammatory, anti-tumor activities. The progress in the total synthesis of this remarkable family of alkaloids is reviewed.

Key words: leuconolam, leuconoxine, mersicarpine, monoterpene indole alkaloid, total synthesis