Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (11): 2704-2708.DOI: 10.6023/cjoc201604051 Previous Articles     Next Articles



梁萌b, 谢宗波a,b, 艾锋b, 乐长高a,b   

  1. a 东华理工大学 江西省质谱科学与仪器2011协同创新中心 南昌 330013;
    b 东华理工大学应用化学系 南昌 330013
  • 收稿日期:2016-04-24 修回日期:2016-06-02 发布日期:2016-07-07
  • 通讯作者: 谢宗波, 乐长高;
  • 基金资助:


Synthesis of Quinoline Derivatives Catalyzed by α-Chymotrypsin

Liang Mengb, Xie Zongboa,b, Ai Fengb, Le Zhanggaoa,b   

  1. a Jiangxi 2011 Joint Center for the Innovative Mass Spectrometry and Instrumentation, East China University of Technology, Nanchang 330013;
    b Department of Applied Chemistry, East China University of Technology, Nanchang 330013
  • Received:2016-04-24 Revised:2016-06-02 Published:2016-07-07
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos.21262002,21462001,21465002),the Program for Changjiang Scholars and Innovative Research Team in University (No.IRT13054),the Natural Science Foundation of Jiangxi Province (No.20142BAB203008).

The α-chymotrypsin-catalyzed Friedländer condensation reaction between 2-aminoaryl ketone and α-methylene ketone was firstly reported, and a series of quinoline derivatives were obtained in moderate to excellent yields. This method is easy to operate and the reaction condition is mild, which not only expands the application of the promiscuity of protease, but also has positive significance for promoting the development of the green chemistry.

Key words: α-chymotrypsin, Friedlä, nder condensation, quinoline derivatives, biocatalysis