Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (3): 959-968.DOI: 10.6023/cjoc202009007 Previous Articles     Next Articles



曾志刚a,b, 桑贤轲a, 袁波c, 吴鸣虎a,b,*(), 张武元c,*()   

  1. a 湖北科技学院核技术与化学生物学院 湖北咸宁 437100
    b 辐射化学与功能材料湖北省重点实验室 湖北咸宁 437100
    c 西安交通大学化学工程与技术学院 西安 710049
  • 收稿日期:2020-09-02 修回日期:2020-09-26 发布日期:2020-10-15
  • 通讯作者: 吴鸣虎, 张武元
  • 基金资助:
    国家自然科学基金(31601675); 西安交通大学青年拔尖人才计划及青年跟踪计划和湖北科技学院博士启动基金(BK201821)

Advances of Haloperoxidases-Catalyzed Green Halogenation Reactions

Zhigang Zenga,b, Xianke Sanga, Bo Yuanc, Minghu Wua,b,*(), Wuyuan Zhangc,*()   

  1. a School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology,Xianning, Hubei 437100
    b Hubei Key Laboratory of Radiation Chemistry and Functional Materials, Xianning, Hubei 437100
    c School of Chemical Engineering and Technology, Xi'an Jiaotong University, Xi'an 710049
  • Received:2020-09-02 Revised:2020-09-26 Published:2020-10-15
  • Contact: Minghu Wu, Wuyuan Zhang
  • About author:
    * Corresponding authors. E-mail: ;
  • Supported by:
    National Natural Science Foundation of China(31601675); Youth Top Talent Program and Tracking Support Program of Xi'an Jiaotong University, and the Ph.D. Start-up Fund of Hubei University of Science and Technology(BK201821)

Halogenation reaction is one of the key reactions in organic synthesis, which acts pivotal part both in laboratory study and industrial applications. Traditional halogenation reactions rely on the use of toxic and hazardous reagents with low selectivity. The enzymatic catalysis bears enormous possibilities to overcome abovementioned bottlenecks remaining in traditional halogenation reactions. Nature has evolved a variety of halogenases that are capable of catalyzing the introduction of halogen atoms in organic substrates. The particular advantage of enzymatic catalysis is that it enables the efficient halogenation reactions occurring at common temperature and pressure with the use of mild halogen sources. The enabled challenging reactions range from halogenation, halohydroxylation, halocyclization to oxidative decarboxylation. In view of the significant potential of enzymatic catalysis in halogenation reactions, the recent advances of halogenase-catalyzed green synthesis are introduced from the perspective of catalytic activity, enzyme stability, substrate concentration, catalytic scope and so on. It is hoped to raise further inspirations in the development of green halogenation reactions catalyzed by halogenases.

Key words: haloperoxidases, biocatalysis, halogenation reactions, organic synthesis, green chemistry