Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (9): 2281-2295.DOI: 10.6023/cjoc201806004 Previous Articles     Next Articles

Special Issue: 合成科学



闫雅如, 齐博文, 莫婷, 王晓晖, 王娟, 史社坡, 刘晓, 屠鹏飞   

  1. 北京中医药大学中药学院 中药现代研究中心 北京 100029
  • 收稿日期:2018-06-01 修回日期:2018-08-10 发布日期:2018-08-14
  • 通讯作者: 刘晓, 屠鹏飞, 史社坡;;
  • 基金资助:


Research Progress of Rhamnosyltransferase

Yan Yaru, Qi Bowen, Mo Ting, Wang Xiaohui, Wang Juan, Shi Shepo, Liu Xiao, Tu Pengfei   

  1. Modern Research Center for Traditional Chinese Medicine, School of Chinese Meteria Medica, Beijing University of Chinese Medicine, Beijing 100029
  • Received:2018-06-01 Revised:2018-08-10 Published:2018-08-14
  • Contact: 10.6023/cjoc201806004;;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 81402809) and the Foundation from Beijing University of Chinese Medicine (No. 2018-JYB-XJQ006).

Rhamnosylation is an important type of glycosylation reaction which is widely involved in organic synthesis and structural modification of natural products. In vivo, rhamnosylation is catalyzed by rhamnosyltransferase that transferred the active rhamnosyl donors to the specific sugar acceptors. A larger number of rhamnosyltransferases have been identified in natural and they often played key roles in the biosynthesis of diverse natural products as well as maintaining the cell structure and physiological functions of biological organisms. Besides, enzymatic rhamnosylation has been an effective complementary method to chemical catalysis in the field of organic glycosylation modifications due to its high catalysis efficiency and specificity, mild reaction conditions as well as environment friendship and so on. In this article, research progresses of rhamnosyltransferase are reviewed based on their enzymatic functions, three dimensional structure investigations, rhamnosyl donors' synthesis, enzymatic catalysis promiscuities, and biochemical catalysis applications. Finally, the future development and application of them are also prospected.

Key words: rhamnosyltransferase, biosynthesis, enzyme catalysis, biocatalysis