Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (2): 520-525.DOI: 10.6023/cjoc201607044 Previous Articles     Next Articles



卢辛未a,b, 谢莹a,b, 王京a,b, 谭镭b, 詹雁b, 阮佳b, 徐超群b   

  1. a 成都中医药大学药学院 成都 610075;
    b 四川省中医药科学院 成都 610041
  • 收稿日期:2016-07-29 修回日期:2016-09-22 发布日期:2016-10-11
  • 通讯作者: 徐超群
  • 基金资助:


Two New Compounds from the Leaves of Paliurus ramosissimus

Lu Xinweia,b, Xie Yinga,b, Wang Jinga,b, Tan Leib, Zhan Yanb, Ruan Jiab, Xu Chaoqunb   

  1. a School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075;
    b Institute of Pharmacy, Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041
  • Received:2016-07-29 Revised:2016-09-22 Published:2016-10-11
  • Supported by:

    Project supported by the National Key Technology Research and Development Program of the Science and Technology Department of Sichuan Province (No. 15ZC1978), and the Sichuan Provincial Research Institute of Science and Technology Achievements Transformation Fund (No. 14010139).

To study chemical constituents in the ethanol extract of Paliurus ramosissimus (Lour.) Poir, two new compounds along with four known compounds were isolated and purified by repeated gel column chromatographies and high performance preparative liquid chromatography. On the basis of spectroscopic methods (HR-ESIMS, 1D-and 2D-NMR), their structures were identified as 2α-(cis-p-hydroxy-cinnamyloxy)-3α-hydroxy-27-(trans-p-hydroxy-cinnamyloxy)betulinic acid (1), 2α-(trans-p-hydroxy-cinnamyloxy)-3α-hydroxy-27-(cis-p-hydroxy-cinnamyloxy)betulinic acid (2), messagenic acid A (3), mes-sagenic acid B (4), betulinaldehyde (5) and β-sitosterol (6). Among them, compounds 1 and 2 were new compounds named as paliurusene A and paliurusene B, which belong to triterpenoids, compounds 3~6 were isolated from this plant for the first time. The anti-tumor activity of compounds 1~3 was evaluated by methyl thiazolyl tetrazolium (MTT) assays. The result showed that compounds 1~3 presented obvious cytotoxicity in vitro against the cancer cell lines.

Key words: Paliurus ramosissimus (Lour.) Poir., pentacyclic triterpenoids, paliurusene A, paliurusene B, anti-tumor