Pepsin-Catalyzed Synthesis of 2,3-Dihydroquinazolin-4(1H)-one Derivatives

doi:10.6023/cjoc201606030

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (2): 514-519.DOI: 10.6023/cjoc201606030 Previous Articles Next Articles

NOTE

胃蛋白酶催化合成2,3-二氢喹唑啉-4(1H)-酮衍生物

谢宗波^a,b, 张士国^b, 姜国芳^b, 梁萌^b, 乐长高^a,b

a 东华理工大学江西省质谱科学与仪器2011协同创新中心南昌 330013;
b 东华理工大学应用化学系南昌 330013

收稿日期:2016-06-20 修回日期:2016-09-17 发布日期:2016-10-18
通讯作者: 姜国芳, 乐长高 E-mail:zhgle@ecit.cn;gfjiang@ecit.cn
基金资助:
国家自然科学基金（Nos.21462001，21465002）、长江学者和创新团队发展计划（No.IRT13054）、江西省自然科学基金（No.20142BAB203008）资助项目.

Pepsin-Catalyzed Synthesis of 2,3-Dihydroquinazolin-4(1H)-one Derivatives

Xie Zongbo^a,b, Zhang Shiguo^b, Jiang Guofang^b, Liang Meng^b, Le Zhanggao^a,b

a Jiangxi 2011 Joint Center for the Innovative Mass Spectrometry and Instrumentation, East China University of Technology, Nanchang 330013;
b Department of Applied Chemistry, East China University of Technology, Nanchang 330013

Received:2016-06-20 Revised:2016-09-17 Published:2016-10-18
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21462001, 21465002), the Program for Changjiang Scholars and Innovative Research Team in University (No. IRT13054), the Natural Science Foundation of Jiangxi Province (No. 20142BAB203008).

1. Pepsin-Catalyzed Synthesis of 2,3-Dihydroquinazolin-4(1H)-one Derivatives.PDF(1128KB)

Abstract

The catalytic property of some hydrolases for the cyclocondensation of aldehydes with 2-aminobenzamide was researched in alcohol solvent, and pepsin was selected as the best catalyst. The reaction conditions were optimized through investigating the temperature, the enzyme loading, the ratio of substrates and the reaction time. Under the optimal conditions, 5 mg of pepsin could catalyze the cyclizing reaction of aldehydes with 2-aminobenzamide, and the corresponding 2,3-dihydroquinazolin-4(1H)-ones were successfully obtained in high yields.

Key words: 2-aminobenzamide, aldehyde, cyclocondensation, 2,3-dihydroquinazolin-4(1H)-ones, pepsin

Cite this article

Xie Zongbo, Zhang Shiguo, Jiang Guofang, Liang Meng, Le Zhanggao. Pepsin-Catalyzed Synthesis of 2,3-Dihydroquinazolin-4(1H)-one Derivatives[J]. Chin. J. Org. Chem., 2017, 37(2): 514-519.

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胃蛋白酶催化合成2,3-二氢喹唑啉-4(1H)-酮衍生物

Pepsin-Catalyzed Synthesis of 2,3-Dihydroquinazolin-4(1H)-one Derivatives

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