Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (4): 810-823.DOI: 10.6023/cjoc201611032 Previous Articles     Next Articles



肖春霞a, 曹林a, 王佳a, 苗银龙a, 范华芳a,b   

  1. a. 西北农林科技大学 陕西省天然产物化学生物学重点实验室 杨凌 712100;
    b. 中国科学院上海有机化学研究所 中国科学院天然产物有机合成化学重点实验室 上海 200032
  • 收稿日期:2016-11-24 修回日期:2016-12-24 发布日期:2017-01-17
  • 通讯作者: 范华芳
  • 基金资助:


Advances in the Collective Synthesis of Lycopodium Alkaloids

Xiao Chunxiaa, Cao Lina, Wang Jiaa, Miao Yinlonga, Fan Huafanga,b   

  1. a. Shaanxi Key Laboratory of Natural Products & Chemical Biology, Northwest A&F University, Yangling 712100;
    b. Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • Received:2016-11-24 Revised:2016-12-24 Published:2017-01-17
  • Contact: 10.6023/cjoc201611032
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21403169, 21502153), the Postdoctoral Science Foundation of China (No. 2013M532084) and the Chinese Universities Scientific Fund (No. 2452015079).

In view of the relevance between chemical structures and biosynthetic pathways of compounds that belong to the same family of natural products, MacMillan et al. (2011) proposed a strategy for the rapid and efficient synthesis of natural product within a family from a common intermediate or a group of similar intermediates, which is termed as collective synthesis. In recent years, this strategy has been applied for the synthesis of multiple family of natural products. Lycopodium alkaloids are a class of structurally diverse alkaloids, and many of them exhibiting good biological activity. In this review, the progress in the collective synthesis of Lycopodium alkaloids is summarized.

Key words: Lycopodium alkaloids, natural products, total synthesis, collective synthesis