Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (6): 1548-1555.DOI: 10.6023/cjoc201612001 Previous Articles     Next Articles



周婷, 王道林, 钱建华, 赵伟   

  1. 渤海大学化学化工学院 辽宁省功能化合物合成与应用重点实验室 锦州 121003
  • 收稿日期:2016-12-01 修回日期:2017-01-11 发布日期:2017-02-17
  • 通讯作者: 王道林
  • 基金资助:


Iodine Promoted Synthesis of Pyrano[3,2-c]quinoline-4,5-diones

Zhou Ting, Wang Daolin, Qian Jianhua, Zhao Wei   

  1. Key Laboratory of Synthesis & Application of Functional Compound, College of Chemistry andChemical Engineering, Bohai University, Jinzhou 121003
  • Received:2016-12-01 Revised:2017-01-11 Published:2017-02-17
  • Contact: 10.6023/cjoc201612001
  • Supported by:

    Project supported by the Innovation Team Project of Liaoning Province Education Department (No. 2015001).

An efficient method for the synthesis of pyrano[3,2-c]quinoline-4,5-dione derivatives via iodine promoted intramolecular cyclization of 1-methyl-3-cinnamoyl-4-hydroxyquinolin-2-one, synthesized from aldol condensation of 1-methyl-3-acetyl-4-hydroxyquinolin-2-one with aromatic aldehydes in the presence of pyridine and PEG-400 under ultrasound irradiation, has been described. This method offers the advantages of a green approach, easy work-up, mild conditions and good yields.

Key words: quinoline, heterocycle, ultrasound irradiation, iodine, synthesis