Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (5): 1069-1087.DOI: 10.6023/cjoc201702001 Previous Articles     Next Articles



马小盼, 刘凤萍, 莫冬亮   

  1. 广西师范大学化学与药学学院 省部共建药用资源化学与药物分子工程国家重点实验室 桂林 541004
  • 收稿日期:2017-02-02 修回日期:2017-03-21 发布日期:2017-04-13
  • 通讯作者: 莫冬亮
  • 基金资助:


Recent Advances in Chan-Evans-Lam Coupling Reaction

Ma Xiaopan, Liu Fengping, Mo Dongliang   

  1. State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry & Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004
  • Received:2017-02-02 Revised:2017-03-21 Published:2017-04-13
  • Contact: 10.6023/cjoc201702001
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21562005, 21602037); “Overseas 100 Talents Program” of Guangxi Higher Education, Natural Science Foundation of Guangxi (No. 2016GXNSFFA380005).

Chan-Evans-Lam reaction has been served as a powerful cross-coupling reaction in organic synthesis since its discovery in the 1990s owing to the feature of mild reaction conditions, functional group tolerance and open-flask chemistry. Up to now, it has been not only extensively utilized in carbon-heteroatom or carbon-carbon bonds formation, but also successfully applied to synthesize natural products and alkaloids. The new strategies of Chan-Evans-Lam reaction in organic synthesis as well as applications in total synthesis in recent five years are discussesed.

Key words: coupling reaction, copper-catalyzed, organic boron reagents, carbon-heteroatom bond formation