Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (6): 1493-1499.DOI: 10.6023/cjoc201710009 Previous Articles     Next Articles



李爽a,b,c, 向恒b,c, 姜瑞航a, 居佳b,c, 焦鹏冲b,c, 苑华磊b,c, 孙宏滨a, 蔡华强b,c   

  1. a 东北大学理学院 沈阳 110819;
    b 中国工程物理研究院化工材料研究所 绵阳 621900;
    c 四川省新材料中心 成都 610000
  • 收稿日期:2017-10-09 修回日期:2017-12-18 发布日期:2018-02-06
  • 通讯作者: 居佳,;孙宏滨,;
  • 基金资助:


Stereoselective Vinylation under Mild Metal-Free Conditions to Synthesize N-Vinylazoles

Li Shuanga,b,c, Xiang Hengb,c, Jiang Ruihanga, Ju Jiab,c, Jiao Pengchongb,c, Yuan Hualeib,c, Sun Hongbina, Cai Huaqiangb,c   

  1. a Department of Chemistry, Northeastern University, Shenyang 110819;
    b Institute of Chemical Materials, China Academy of Engineering Physics, Mianyang 621900;
    c New Material Research Center in Sichuan, Chengdu 610000
  • Received:2017-10-09 Revised:2017-12-18 Published:2018-02-06
  • Contact: 10.6023/cjoc201710009;
  • Supported by:

    Project supported by the Sci-Tech Innovation Funds for Institute of Chemical Materials (No. KJCX-201502).

A metal-free synthetic protocol for N-vinylazoles has been developed. Twenty-two structurally diversed N-vinylazoles including 15 new compounds are obtained with good to high yield at near room temperature, and all of products consist trans-alkene moieties with high stereoselectivity.

Key words: metal-free, C—N coupling, vinylation, azoles, stereoselectivity