Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (8): 1940-1948.DOI: 10.6023/cjoc201804004 Previous Articles     Next Articles

Special Issue: 碳氢活化合辑2018-2019



徐琳琳a, 徐辉c, 林海霞a, 戴辉雄b   

  1. a 上海大学化学系 上海大学创新药物研究中心 上海 200444;
    b 中国科学院上海药物研究所 药物化学研究室 上海 201203;
    c 中国科学院上海有机化学研究所 金属有机化学国家重点实验室 上海 200032
  • 收稿日期:2018-04-02 修回日期:2018-04-23 发布日期:2018-05-03
  • 通讯作者: 林海霞, 戴辉雄;
  • 基金资助:


Progress in the Synthesis of Primary Anilines via C-H Bond Functionalization

Xu Linlina, Xu Huic, Lin Haixiaa, Dai Huixiongb   

  1. a Department of Chemistry, Innovative Drug Research Center, Shanghai University, Shanghai 200444;
    bDepartment of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203;
    c State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • Received:2018-04-02 Revised:2018-04-23 Published:2018-05-03
  • Contact: 10.6023/cjoc201804004;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21772211) and the Youth Innovation Promotion Association of Chinese Academy of Sciences (No. 2014229).

Primary anilines are widely used in pharmaceutical, agrochemicals and material chemistry. In recent years, the green and efficient methods for constructing carbon-nitrogen (C-N) bonds to introduce primary amines has been one of the hottest topics in chemical synthesis. The direct C-H primary amination of aromatic compounds have received considerable attention due to its high efficiency and practicality. The recent progress in the C-H primary amination of aromatic compounds reactions is reviewed. Furthermore, the synthetic challenge and prospect in the future development for the synthesis of primary anilines through direct C-H amination are summarized.

Key words: amination, C-H bond functionalization, primary anilines, transition-metal catalyzed