Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (11): 2927-2936.DOI: 10.6023/cjoc201805042 Previous Articles     Next Articles

Special Issue: 荧光探针-生物传感合辑 有机超分子化学合辑



熊斐, 李莉   

  1. 中国医学科学院&北京协和医学院药物研究所 活性物质发现与适药化研究北京市重点实验室 北京 100050
  • 收稿日期:2018-05-20 修回日期:2018-06-05 发布日期:2018-06-22
  • 通讯作者: 李莉
  • 基金资助:


Advances in Development of Chiral Sensors

Xiong Fei, Li Li   

  1. a Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050
  • Received:2018-05-20 Revised:2018-06-05 Published:2018-06-22
  • Supported by:

    Project supported by the Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (No. 2016-I2M-3-009).

Chiral compounds play an essential role in asymmetric synthesis, biology, medical field and pharmacology. It is necessary to establish fast, sensitive and high enantioselective chiral analysis methods. Chiral sensors, which could determine the absolute configuration and the value of enantiomeric excess of enantiomers, have the advantages of simple, rapid, sensitive and real-time. Herein, the review is focused on the recent progress of chiral fluorescent sensors, circular dichroism sensors, UV-Vis sensors, NMR sensors and MS sensors. Their characteristics, sensing mechanism and applications in chiral recognition are reviewed, and the prospects of chiral sensors are also discussed.

Key words: chiral sensor, chiral compound, chiral recognition, enantiomeric excess, absolute configuration