Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (3): 867-872.DOI: 10.6023/cjoc201806029 Previous Articles     Next Articles



黄朋勉a, 周智慧a, 杜永磊b, 庞怀林b, 吕亮b   

  1. a 长沙理工大学化学与食品工程学院 长沙 410114;
    b 上海泰禾国际贸易有限公司 上海 200335
  • 收稿日期:2018-06-19 修回日期:2018-09-05 发布日期:2018-10-26
  • 通讯作者: 黄朋勉, 吕亮;
  • 基金资助:


Synthesis and Fungicidal Activity of N-Alkoxyl Amide Derivatives

Huang Pengmiana, Zhou Zhihuia, Du Yongleib, Pang Huailinb, Lü Liangb   

  1. a School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha 410114;
    b CAC Shanghai International Trading Co., Ltd., Shanghai 200335
  • Received:2018-06-19 Revised:2018-09-05 Published:2018-10-26
  • Contact: 10.6023/cjoc201806029;
  • Supported by:

    Project supported by the Changsha Science and Technology Project (Nos. kq1801163, kq1801052) and the Hunan Provincial Engineering Research Center for Food Processing of Aquatic Biotic Resources (No. 2018KJY08).

In order to find lead compounds with high fungicidal activity, the phenyl moiety of pydiflumetofen was replaced by substituted 1-phenyl-3-hydroxylpyrazole moiety of pyraclostrobin according to the method of active substructure combination. 12 novel N-alkoxyl amides were synthesized and their structures were confirmed by 1H NMR, 13C NMR and HRMS. Preliminary fungicidal activity screening results showed that some analogues exhibited certain fungicidal activity against Phakopsora pachyrhizi, Pseudoperonospora cubensis or Erysiphe cichoracearum, compound 3a displayed 95% protective effect against Erysiphe cichoracearum at 100 mg/L.

Key words: pydiflumetofen, amide, pesticide, fungicidal activity