Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (1): 257-264.DOI: 10.6023/cjoc201807018 Previous Articles     Next Articles

Articles

五氟乙基硫叶立德:一类新的亲电五氟乙基化试剂

刘亚飞a, 葛航铭a, 吕龙b, 沈其龙a   

  1. a 中国科学院上海有机化学研究所 中国科学院有机氟化学重点实验室 分子合成科学卓越研究中心 中国科学院大学 上海 200032;
    b 中国科学院上海有机化学研究所 上海 200032
  • 收稿日期:2018-07-09 修回日期:2018-08-02 出版日期:2019-01-25 发布日期:2018-09-10
  • 通讯作者: 吕龙, 沈其龙 E-mail:lulong@mail.sioc.ac.cn;shenql@mail.sioc.ac.cn
  • 基金资助:

    国家自然科学基金(Nos.21625206,21632009,21572258,21572259,21421002)、中国科学院战略性先导科技专项B类(No.XDB20000000)资助项目.

Pentafluoroethyl-Substituted Sulfonium Ylides: New Electrophilic Pentafluoroethylating Reagents

Liu Yafeia, Ge Hangminga, Lu Longb, Shen Qilonga   

  1. a Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200032;
    b Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • Received:2018-07-09 Revised:2018-08-02 Online:2019-01-25 Published:2018-09-10
  • Contact: 10.6023/cjoc201807018 E-mail:lulong@mail.sioc.ac.cn;shenql@mail.sioc.ac.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21625206, 21632009, 21572258, 21572259, 21421002) and the Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDB20000000).

Two electrophilic pentafluoroethylating reagents of pentafluoroethyl(p-methylphenyl)sulfonium bis(carbometh- oxy)methylide (4a) and pentafluoroethyl(4-nitrophenyl)sulfonium bis(carbomethoxy)methylide (4b), and their reactions under mild conditions with β-ketoesters, aryl iodides and heteroaromatics are described.

Key words: fluorine, pentafluoroethyl, sulfonium ylide, electrophilic