Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (3): 873-877.DOI: 10.6023/cjoc201808006 Previous Articles     Next Articles



沈涛a, 欧阳博a,b, 周少东a, 钱超a, 陈新志a   

  1. a 浙江大学浙江省化工高效制造技术重点实验室 杭州 310027;
    b 浙江花园生物高科有限公司 东阳 322121
  • 收稿日期:2018-08-07 修回日期:2018-09-28 发布日期:2018-10-26
  • 通讯作者: 钱超
  • 基金资助:


Efficient, Solvent-Free Aminolysis of Monoesters Catalyzed by Sodium

Shen Taoa, Ouyang Boa,b, Zhou Shaodonga, Qian Chaoa, Chen Xinzhia   

  1. a Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology, Zhejiang University, Hangzhou 310027;
    b Zhejiang Garden Biochemical High-Tech Co., LTD, Dongyang 322121
  • Received:2018-08-07 Revised:2018-09-28 Published:2018-10-26
  • Contact: 10.6023/cjoc201808006
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21476194) and the National Key Research and Development Program of China (No. 2016YFB0301800).

An efficient, solvent-free procedure using sodium as catalyst for the aminolysis of monoesters is reported. A detailed comparison of catalysts between sodium and sodium amide was made. It was found that the fresh sodium amide by in-situ synthesis of sodium with ammonia was more active than the indirectly adding sodium amide. As compared to the previously reported approaches, the procedure given in this work is much faster and performed under mild conditions. Furthermore, this procedure is applied successfully for the aminolysis of other monoesters.

Key words: monoester, aminolysis, sodium, sodium amide