Synthesis and Fungicidal Activity of N-Alkoxyl Amide Derivatives

doi:10.6023/cjoc201806029

Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (3): 867-872.DOI: 10.6023/cjoc201806029 Previous Articles Next Articles

Notes

N-烷氧基取代酰胺类化合物的合成及杀菌活性

黄朋勉^a, 周智慧^a, 杜永磊^b, 庞怀林^b, 吕亮^b

a 长沙理工大学化学与食品工程学院长沙 410114;
b 上海泰禾国际贸易有限公司上海 200335

收稿日期:2018-06-19 修回日期:2018-09-05 发布日期:2018-10-26
通讯作者: 黄朋勉, 吕亮 E-mail:huangpengmian@126.com;liang_lv@cacch.com
基金资助:
长沙市科技计划（Nos.kq1801163，kq1801052）和湖南省水生资源食品加工工程技术研究中心开放基金（No.2018KJY08）资助项目.

Synthesis and Fungicidal Activity of N-Alkoxyl Amide Derivatives

Huang Pengmian^a, Zhou Zhihui^a, Du Yonglei^b, Pang Huailin^b, Lü Liang^b

a School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha 410114;
b CAC Shanghai International Trading Co., Ltd., Shanghai 200335

Received:2018-06-19 Revised:2018-09-05 Published:2018-10-26
Contact: 10.6023/cjoc201806029 E-mail:huangpengmian@126.com;liang_lv@cacch.com
Supported by:
Project supported by the Changsha Science and Technology Project (Nos. kq1801163, kq1801052) and the Hunan Provincial Engineering Research Center for Food Processing of Aquatic Biotic Resources (No. 2018KJY08).

1. Synthesis and Fungicidal Activity of N-Alkoxyl Amide Derivatives.PDF(1917KB)

Abstract

In order to find lead compounds with high fungicidal activity, the phenyl moiety of pydiflumetofen was replaced by substituted 1-phenyl-3-hydroxylpyrazole moiety of pyraclostrobin according to the method of active substructure combination. 12 novel N-alkoxyl amides were synthesized and their structures were confirmed by ¹H NMR, ¹³C NMR and HRMS. Preliminary fungicidal activity screening results showed that some analogues exhibited certain fungicidal activity against Phakopsora pachyrhizi, Pseudoperonospora cubensis or Erysiphe cichoracearum, compound 3a displayed 95% protective effect against Erysiphe cichoracearum at 100 mg/L.

Key words: pydiflumetofen, amide, pesticide, fungicidal activity

Cite this article

Huang Pengmian, Zhou Zhihui, Du Yonglei, Pang Huailin, Lü Liang. Synthesis and Fungicidal Activity of N-Alkoxyl Amide Derivatives[J]. Chin. J. Org. Chem., 2019, 39(3): 867-872.

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N-烷氧基取代酰胺类化合物的合成及杀菌活性

Synthesis and Fungicidal Activity of N-Alkoxyl Amide Derivatives

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